Buy Epitalon 10mg (Epithalon) — Ala-Glu-Asp-Gly Research Peptide
Epitalon (also spelled Epithalon; AEDG peptide) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly [R1]. It was designed from the amino-acid composition of epithalamin, a polypeptide extract of the bovine pineal gland, and proposed as one of its active components [R2]. Published research has examined epitalon in cell-culture models of telomerase and gene expression, and in rodent and primate models of aging and pineal function [R3]–[R7]. Most of that work comes from one research group, and recent reviews describe the compound as biologically active but clinically unproven [R2][R8].
Purity ≥99% by HPLC · Identity confirmed by mass spectrometry · Batch COA below
For laboratory research use only. Not for human or veterinary use.
Epitalon
Specifications
| Property | Value |
|---|---|
| Compound | Epitalon (Epithalon) |
| Sequence | H-Ala-Glu-Asp-Gly-OH (AEDG) |
| CAS number | 307297-39-8 |
| PubChem CID | 219042 |
| Molecular formula | C14H22N4O9 |
| Molecular weight | 390.35 g/mol |
| Amino acid count | 4 |
| Synonyms | Epithalon; Epitalone; AEDG peptide; Ala-Glu-Asp-Gly |
| Physical form | White lyophilized powder |
| Purity | ≥99% by HPLC (confirm against the batch COA before publishing) |
| Identity | Mass spectrometry, per batch COA |
| Solubility | Water-soluble; see the batch COA for solvent guidance |
| Storage | Lyophilized: −20 °C, protected from light and moisture |
| Contents | 10 mg per vial |
Epitalon Research Overview
Telomerase and telomeres
In a 2003 study, epitalon increased expression of the telomerase catalytic subunit, telomerase activity, and telomere length in cultured human fetal fibroblasts [R3]. An independent 2025 study in human cell lines reported telomere elongation in normal cells through telomerase upregulation but in breast-cancer cell lines through the telomerase-independent ALT pathway [R9]. That paper was later corrected.
Rodent aging models
In female SHR mice, epitalon did not change mean lifespan or total tumor incidence, though some secondary measures differed from controls [R4]. In rats, effects on lifespan depended on the light regime and were absent under a standard light/dark cycle [R5].
Pineal and circadian studies
In a small study of senescent rhesus monkeys (three animals per group), epitalon was associated with higher evening melatonin levels; no effect was seen in young animals [R6].
Gene expression
In human gingival mesenchymal stem cells, epitalon increased mRNA of neurogenesis markers (Nestin, GAP43, β-Tubulin III, Doublecortin) by 1.6–1.8-fold; proposed histone binding was modeled computationally, not measured [R7].
Limits of the evidence
Nearly all studies come from the St. Petersburg Institute of Bioregulation and Gerontology. Sample sizes are small, several results are null or condition-dependent, no pharmacokinetic study exists in any species, and no adequately powered randomized human trial has been published [R2][R8].
For a fuller summary of each research area, see what epitalon is used for in research.
Regulatory Status
Epitalon is not approved by the FDA for any use. In July 2026, an FDA advisory committee narrowly voted to recommend it for the 503A bulk-substances list for compounding; the vote is non-binding, and FDA had not changed the list as of October 2026 [R10][R11].
Epitalon FAQ
What is epitalon?
Epitalon is a synthetic four-amino-acid peptide (Ala-Glu-Asp-Gly), CAS 307297-39-8, studied in laboratory models of telomere biology, gene expression, and pineal function [R1][R2].
Is epitalon the same as epithalon?
Yes. Epitalon and Epithalon are two spellings of the same synthetic tetrapeptide. Epithalamin is different: it is the pineal-gland extract that epitalon was designed from [R2]. See our full guide: epitalon vs epithalon vs epithalamin.
Does epitalon lengthen telomeres?
Some cell-culture studies report telomere elongation in human cells [R3][R9]; in cancer cell lines it occurred through the ALT pathway rather than telomerase [R9]. No controlled human study has shown it.
Is epitalon FDA-approved?
No. It is not an approved drug. A July 2026 advisory committee vote on compounding was non-binding and has not changed its status [R10][R11].
How should epitalon be stored?
Store the lyophilized powder at −20 °C, protected from light and moisture. Follow the batch COA for solution handling.
Can epitalon be used by humans?
No. Sequora supplies epitalon as a research chemical for in-vitro and laboratory use only.
Epitalon is listed in our Bioregulators category.
References
How we select and verify sources: Research Sources & Editorial Standards
- PubChem. Epitalon, CID 219042. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov/compound/219042
- Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł. Overview of Epitalon—highly bioactive pineal tetrapeptide with promising properties. Int J Mol Sci. 2025;26(6):2691. doi:10.3390/ijms26062691. PMID 40141333.
- Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590–592. doi:10.1023/A:1025493705728. PMID 12937682.
- Anisimov VN, Khavinson VKh, Popovich IG, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193–202. doi:10.1023/A:1025114230714. PMID 14501183.
- Vinogradova IA, Bukalev AV, Zabezhinski MA, et al. Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes. Bull Exp Biol Med. 2007;144(6):825–830. doi:10.1007/s10517-007-0441-z. PMID 18856211.
- Khavinson V, Goncharova N, Lapin B. Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys. Neuroendocrinol Lett. 2001;22(4):251–254. Full text (PDF).
- Khavinson V, Diomede F, Mironova E, et al. AEDG peptide (Epitalon) stimulates gene expression and protein synthesis during neurogenesis: possible epigenetic mechanism. Molecules. 2020;25(3):609. doi:10.3390/molecules25030609. PMID 32019204.
- Jain A, Gallacher DM, Issa MA, et al. Epitalon and epithalamin: a narrative review of mechanistic, preclinical, and clinical evidence. Int J Mol Sci. 2026;27(19):8922. doi:10.3390/ijms27198922.
- Al-Dulaimi S, Thomas RS, Matta S, Roberts T. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025;26(5):178. doi:10.1007/s10522-025-10315-x. PMID 40908429.
- U.S. Food and Drug Administration. Bulk drug substances used in compounding under section 503A of the FD&C Act. fda.gov
- McDermott Will & Schulte. Bulk list bound? PCAC backs majority of peptides in two-day public meeting. July 2026. mcdermottlaw.com
Research Use Only. Sequora Peptides supplies this product as a research chemical for in-vitro and laboratory use by qualified researchers. It is not a drug, dietary supplement, or food, and is not intended for human or veterinary use.
